There are lots of reasons women – and men – might experience anorgasmia. I’m only going to talk about one – because it’s the one that affects me. Medication. Specifically, SNRI anti-depressant medication. All medication has an effect – that’s why we prefer prescriptions to placebos. Side effects are unwanted consequences of medication and when we treat conditions pharmacologically, we weigh the pros and cons of our options. I’ve been on my current anti-depressant two years. At the lowest dose I struggled with orgasm, and at my current dose it is an impossibility.